Gene information
Official symbol HGF
Official full name hepatocyte growth factor
Gene type protein-coding gene
Chromosome7q21.11
Alias symbolSF; F-TCF; HGFB; HPTA
Previous symbolDFNB39
Resources
Entrez Gene 3082
HGNC HGNC:4893
Ensembl ENSG00000019991
Vega OTTHUMG00000023804
UCSC uc003uhl.4
GO terms: 114 records
GO Description Category LogP Number of genes Detail
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001837 epithelial to mesenchymal transition GO Biological Processes -7.70350405 17 More
GO:0001889 liver development GO Biological Processes -10.3922429 25 More
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010506 regulation of autophagy GO Biological Processes -5.54010569 34 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010639 negative regulation of organelle organization GO Biological Processes -2.25995266 25 More
GO:0010821 regulation of mitochondrion organization GO Biological Processes -7.09757912 23 More
GO:0010823 negative regulation of mitochondrion organization GO Biological Processes -4.35719226 10 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0010975 regulation of neuron projection development GO Biological Processes -5.89330331 41 More
GO:0010976 positive regulation of neuron projection development GO Biological Processes -4.13061709 18 More
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -15.9250248 30 More
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -18.2876323 28 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031091 platelet alpha granule GO Cellular Components -43.3287145 36 More
GO:0031093 platelet alpha granule lumen GO Cellular Components -40.0105787 31 More
GO:0031099 regeneration GO Biological Processes -17.4553316 23 More
GO:0031100 animal organ regeneration GO Biological Processes -17.1438387 17 More
GO:0031330 negative regulation of cellular catabolic process GO Biological Processes -6.88355184 32 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031346 positive regulation of cell projection organization GO Biological Processes -6.78114948 37 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0031641 regulation of myelination GO Biological Processes -3.81944625 9 More
GO:0031644 regulation of nervous system process GO Biological Processes -8.22607591 24 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032653 regulation of interleukin-10 production GO Biological Processes -10.1959901 18 More
GO:0032675 regulation of interleukin-6 production GO Biological Processes -28.2553997 51 More
GO:0032733 positive regulation of interleukin-10 production GO Biological Processes -8.60591296 9 More
GO:0032872 regulation of stress-activated MAPK cascade GO Biological Processes -11.6818048 20 More
GO:0033137 negative regulation of peptidyl-serine phosphorylation GO Biological Processes -5.46031079 9 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042056 chemoattractant activity GO Molecular Functions -15.3237868 13 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -5.11653120 8 More
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -14.7594418 39 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0045667 regulation of osteoblast differentiation GO Biological Processes -10.7517956 27 More
GO:0045669 positive regulation of osteoblast differentiation GO Biological Processes -8.83631876 18 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0048762 mesenchymal cell differentiation GO Biological Processes -16.1250183 37 More
GO:0050673 epithelial cell proliferation GO Biological Processes -5.54644403 9 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.9747849 34 More
GO:0050918 positive chemotaxis GO Biological Processes -15.2518887 14 More
GO:0051052 regulation of DNA metabolic process GO Biological Processes -4.01973325 42 More
GO:0051054 positive regulation of DNA metabolic process GO Biological Processes -3.76901955 13 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0060485 mesenchyme development GO Biological Processes -18.0238 46 More
GO:0061008 hepaticobiliary system development GO Biological Processes -10.9353398 26 More
GO:0070302 regulation of stress-activated protein kinase signaling cascade GO Biological Processes -11.5600448 20 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0090199 regulation of release of cytochrome c from mitochondria GO Biological Processes -6.79373102 8 More
GO:0090201 negative regulation of release of cytochrome c from mitochondria GO Biological Processes -3.92689699 4 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:1900407 regulation of cellular response to oxidative stress GO Biological Processes -21.4526227 33 More
GO:1900744 regulation of p38MAPK cascade GO Biological Processes -6.86981007 8 More
GO:1901031 regulation of response to reactive oxygen species GO Biological Processes -8.30091899 13 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO Biological Processes -11.7829637 12 More
GO:1902882 regulation of response to oxidative stress GO Biological Processes -20.0046302 33 More
GO:1902947 regulation of tau-protein kinase activity GO Biological Processes -4.91299256 6 More
GO:1903201 regulation of oxidative stress-induced cell death GO Biological Processes -18.4601079 28 More
GO:1903202 negative regulation of oxidative stress-induced cell death GO Biological Processes -17.0330784 23 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1905330 regulation of morphogenesis of an epithelium GO Biological Processes -7.22524154 15 More
GO:2000027 regulation of animal organ morphogenesis GO Biological Processes -7.86416421 22 More
GO:2000116 regulation of cysteine-type endopeptidase activity GO Biological Processes -14.4496812 41 More
GO:2000117 negative regulation of cysteine-type endopeptidase activity GO Biological Processes -4.79670615 8 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000278 regulation of DNA biosynthetic process GO Biological Processes -3.75179201 8 More
GO:2000573 positive regulation of DNA biosynthetic process GO Biological Processes -1.81070423 4 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO Biological Processes -19.1764933 21 More
KEGG pathways: 13 records
KEGG Description Category LogP Number of genes Detail
hsa01521 EGFR tyrosine kinase inhibitor resistance KEGG Pathway -6.02704244 9 More
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04015 Rap1 signaling pathway KEGG Pathway -8.52596130 17 More
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04510 Focal adhesion KEGG Pathway -16.5268196 41 More
hsa05144 Malaria KEGG Pathway -31.5561809 24 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05205 Proteoglycans in cancer KEGG Pathway -18.5545131 27 More
hsa05218 Melanoma KEGG Pathway -5.33688125 8 More
hsa05225 Hepatocellular carcinoma KEGG Pathway -5.07719186 21 More
hsa05226 Gastric cancer KEGG Pathway -5.33653529 20 More
Drug-Gene interaction
view
Related drugs: 12 records
Drug name Interaction type Source PMID View
aspirin NCI 11981761 view
epigalocatechin gallate NCI 16449979 view
ficlatuzumab inhibitorantibody TALCMyCancerGenomeTdgClinicalTrialChemblInteractionsTTD view
imatinib mesylate NCI 11439348 view
methotrexate NCI 10732770 view
mp-0250 TTD view
reserpine NCI 16081063 view
resveratrol NCI 15672869 view
rilotumumab inhibitorantibody TALCMyCancerGenomeTdgClinicalTrialChemblInteractionsCancerCommons view
streptozocin NCI 12403787 view
thalidomide NCI 15939924 view
wortmannin NCI 9603913 view
Related studies: 15 records
Molecular factor Omics type Application Objective MI type Reference
hepatocyte growth factor proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Matsumori A et al. Biochem Biophys Res Commun. 1996
hepatocyte growth factor proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Sato T et al. J Cardiol. 1998
hepatocyte growth factor proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Sato T et al. Heart Vessels. 1997
hepatocyte growth factor proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Sato T et al. Jpn Circ J. 1999
hepatocyte growth factor proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Zhu Y et al. Heart. 2000
hepatocyte growth factor proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Suzuki H et al. J Cardiol. 2000
hepatocyte growth factor proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Soeki T et al. Cardiology. 2000
hepatocyte growth factor proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Shimada Y et al. Circ J. 2002
hepatocyte growth factor proteomics left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Soeki T et al. Circ J. 2002
hepatocyte growth factor proteomics reperfusion therapy[treatment (other)] acute myocardial infarction Seko Y et al. Clin Sci (Lond). 2004
hepatocyte growth factor proteomics exercise[other] acute myocardial infarction Yasuda S et al. Circ J. 2004
hepatocyte growth factor proteomics death;heart failure hospitalization[prognosis (bad)] acute anterior myocardial infarction Lamblin N et al. Eur J Heart Fail. 2011
hepatocyte growth factor proteomics death;heart failure hospitalization[prognosis (bad)] acute anterior myocardial infarction Lamblin N et al. Eur J Heart Fail. 2011
hepatocyte growth factor proteomics death;heart failure hospitalization[prognosis (bad)] acute anterior myocardial infarction Lamblin N et al. Eur J Heart Fail. 2011
hepatocyte growth factor proteomics ST elevation myocardial infarction[diagnosis] ST elevation myocardial infarction Konopka A et al. Kardiol Pol. 2013
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